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回肠末端是小肠疾病的好发部位，非特异性末端回肠炎是一种常见的肠道炎症性疾病，其发病机制复杂，涉及多种因素。本文概述了其致病因素及机制，包括结肠-回肠反流、机械屏障破坏、免疫功能紊乱(如黏膜免疫系统、Toll样受体、白介素等细胞因子、潘氏细胞及NOD2)、肠道微生物组变化；还探讨了近年来的药物治疗进展，包括益生菌、抗菌药物、小剂量抗焦虑抑郁药物。
Abstract：The terminal ileum is a frequent location for small intestinal diseases, and non-specific terminal ileitis represents a common inflammatory bowel disease with a multifaceted pathogenesis involving various factors. This review provided an overview of the pathogenic factors and mechanisms, encompassing colon-ileum reflux, disruption of the mechanical barrier, immune dysregulation(such as mucosal immune system, Toll-like receptors, interleukins, Paneth cells, and NOD2), alterations in the intestinal microbiome, and recent advancements in drug therapy including probiotics, antibiotics, and low-dose anti-anxiety and antidepressant medications.
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基本信息:
中图分类号:R574
引用信息:
[1]段欣欣,王岚.非特异性末端回肠炎发病机制及药物治疗的研究进展[J].胃肠病学和肝病学杂志,2025,34(11):1583-1586.
基金信息:
山西省教育厅高校科技创新计划(2022L180)
2025-11-20
2025-11-20