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胰腺癌作为恶性程度最高的消化道肿瘤之一,其5年生存率不足10%的严峻现状亟待突破性研究。ATP依赖性染色质重塑因子通过重塑染色质空间构象、调节组蛋白修饰及核小体定位等,在胰腺癌发生发展过程中发挥至关重要的作用。染色质重塑因子主要包括SWI/SNF、ISWI、CHD和INO80四大家族,不同家族成员在胰腺癌中作用各异。本文将对染色质重塑因子在胰腺癌中的作用进行概述。
Abstract:Pancreatic cancer, one of the most aggressive digestive tract cancers, has a dismal 5-year survival rate of less than 10%, underscoring the urgent need for breakthrough research. ATP-dependent chromatin remodelers play a pivotal role in the initiation and progression of pancreatic cancer by regulating chromatin structure, histone modifications, and nucleosome positioning. These chromatin remodelers are classified into four main families: SWI/SNF, ISWI, CHD, and INO80, with each family exhibiting distinct functions in the context of pancreatic cancer. In this article, we provided a comprehensive overview of the roles of chromatin remodelers in pancreatic cancer.
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基本信息:
DOI:
中图分类号:R735.9
引用信息:
[1]刘祥政,陈默.胰腺癌中染色质重塑因子的调控机制研究[J].胃肠病学和肝病学杂志,2025,34(09):1258-1261.
基金信息:
北京市自然科学基金资助项目(JQ23024)