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目的 研究不同类型结肠息肉患者血浆硫氧还蛋白还原酶(thioredoxin reductase, TrxR)的水平变化及临床意义。方法 随机选取在南京市第二医院消化病诊疗中心住院诊治的结肠息肉患者131例作为观察组，根据病理类型将结肠息肉患者分为增生性息肉组和腺瘤性息肉组，根据异型增生程度进一步将腺瘤性息肉患者分为轻度异型增生组、中度异型增生组及结肠早癌组，结肠早癌包括重度异型增生及黏膜内癌；同时选取健康体检者85名作为对照组。比较各组患者外周血TrxR活性水平。结果 结肠息肉组外周血TrxR水平明显高于对照组(P<0.05)。腺瘤性息肉组外周血TrxR水平明显高于增生性息肉组(P<0.05)。结肠早癌组外周血TrxR水平明显高于中度异型增生组和轻度异型增生组(P<0.05)。中度异型增生组与轻度异型增生组外周血TrxR水平比较差异无统计学意义(P>0.05)。高危腺瘤组外周血TrxR水平明显高于非高危腺瘤组(P<0.05)。结论 TrxR在腺瘤性息肉患者外周血中水平升高，且在进展性腺瘤患者中升高更加显著。
Abstract：Objective To investigate the level changes and clinical significance of plasma thioredoxin reductase(TrxR) in patients with different types of colonic polyps.Methods A total of 131 patients diagnosed with colorectal polyps and hospitalized at the Digestive Disease Diagnosis and Treatment Center of the Second Hospital of Nanjing were randomly selected as the observation group. The colorectal polyp patients were classified into a hyperplastic polyp group and an adenomatous polyp group based on pathological type. The adenomatous polyp patients were further subcategorized into mild dysplasia, moderate dysplasia, and early colorectal cancer groups according to the degree of dysplasia. The early colorectal cancer group included cases of high-grade dysplasia and intramucosal carcinoma. Additionally, 85 healthy individuals undergoing physical examinations were selected as the control group. The activity levels of TrxR in peripheral blood were compared among the groups.Results TrxR levels in peripheral blood were significantly higher in the colorectal polyp group compared to the control group(P<0.01). TrxR levels in peripheral blood were significantly higher in the adenomatous polyp group compared to the hyperplastic polyp group(P<0.05). TrxR levels in peripheral blood were significantly higher in the early colorectal cancer group compared to both the moderate dysplasia group and the mild dysplasia group(P<0.05). No significant difference in TrxR levels was observed between the moderate dysplasia group and the mild dysplasia group. TrxR levels in peripheral blood were significantly higher in the high-risk adenoma group compared to the non-high-risk adenoma group(P<0.05).Conclusion TrxR levels are elevated in the peripheral blood of patients with adenomatous polyps, and this elevation is more significant in patients with progressive adenomas.
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基本信息:
DOI：
中图分类号:R574.6
引用信息:
[1]涂宏飞,孔方,殷霖霖,等.硫氧还蛋白还原酶在不同类型结肠息肉患者中的表达及意义[J].胃肠病学和肝病学杂志,2025,34(09):1295-1297+1304.
基金信息:
十三五南京市卫生青年人才培养工程(QRX17155)